Diagnostic Microbiology & Infectious Disease
Volume 45, Issue 1 , Pages 77-79 , January 2003

Emergence of an IMP-like metallo-enzyme in an Acinetobacter baumannii clinical strain from a Brazilian teaching hospital

  • Ana C Gales

      Affiliations

    • Laboratório Alerta, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil
    • Corresponding Author InformationCorresponding author: Tel.: +55-11-5081-8020; fax: +55-11-5571-5180
    • ,
  • Maria C.B Tognim

      Affiliations

    • Laboratório Alerta, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil
    • Division of Microbiology, Universidade Estadual de Maringá, Paraná, Brazil
    • ,
  • Adriana O Reis

      Affiliations

    • Laboratório Alerta, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil
    • ,
  • Ronald N Jones

      Affiliations

    • The Jones Group/JMI Laboratories, North Liberty, IA, USA
    • ,
  • H.élio S Sader

      Affiliations

    • Laboratório Alerta, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil

Received 15 July 2002 ,Accepted 15 July 2002.

References 

  1. Arakawa Y, Shibata N, Shibayama K, Kurokawa H, & Yagi T, et al.  Convenient test for screening metallo-beta-lactamase-producing gram-negative bacteria by using thiol compounds. J Clin Microbiol. 2000;38:40–43
  2. Bou G, Martínez-Beltrán J. Cloning, nucleotide sequencing, and analysis of the gene encoding an AmpC β-lactamase in Acinetobacter baumannii. J Clin Microbiol. 2000;44:428–432
  3. Chu YW, Afzal-Shah M, Houang ET, Palepou MI, & Lyon DJ, et al.  IMP-4, a novel metallo-beta-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998. Antimicrob Agents Chemother. 2001;45:710–714
  4. Costa SF, Woodcock J, Gill M, Wise R, & Barone AA, et al.  Outer-membrane proteins pattern and detection of beta-lactamases in clinical isolates of imipenem-resistant Acinetobacter baumannii from Brazil. Int J Antimicrob Agents. 2000;13:175–182
  5. Da Silva GJ, Leitao R, Peixe L. Emergence of carbapenem-hydrolyzing enzymes in Acinetobacter baumannii clinical isolates. J Clin Microbiol. 1999;37:2109–2110
  6. Gales AC, Jones RN, Forward KR, Linares J, Sader HS, Verhoef J. Emerging importance of multidrug-resistant Acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients (geographic patterns, epidemiological features, and trends in the SENTRY Antimicrobial Surveillance Program (1997–1999)). Clin Infect Dis. 2001;32:S104–S113
  7. Gales AC, Sader HS, Sinto S, Santos OP, Mendes CF. In vitro activity of ampicillin-sulbactam against multiresistant Acinetobacter baumannii strains. J Chemother. 1986;8:416–419
  8. Gibb AP, Tribuddharat C, Moore RA, Louie TJ, & Krulicki W, et al.  Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new blaIMP allele, blaIMP-7. Antimicrob Agents Chemother. 2002;46:255–258
  9. Gots JS. The detection of penicilinase-producing properties of microorganisms. Science. 1945;102:309
  10. Levin AS, Barone AA, Penco J, Santos MV, Marinho IS, et al.  Intravenous colistin as therapy for nosocomial infections caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. Clin Infect Dis. 1999;28:1008–1011
  11. National Committee for Clinical Laboratory Standards Methods for dilution antimicrobial susceptibility test for bacteria that grow aerobically, fifth edition . Approved standard M7-A5. Wayne, PA: National Committee for Clinical Laboratory Standards; 2000;
  12. Osano E, Arakawa Y, Wacharotayankun R, Ohta M, Horii T, et al.  Molecular characterization of an enterobacterial metallo-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance. Antimicrob Agents Chemother. 1994;38:71–78
  13. Riccio ML, Franceschini N, Boschi L, Caravelli B, Cornaglia G, et al.  Characterization of the metallo-beta-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of bla(IMP) allelic variants carried by gene cassettes of different phylogeny. Antimicrob Agents Chemother. 2000;44:1229–1235
  14. Walsh TR, Bolmström A, Qwärnström A, Gales AC, Etest MBL: A new approach for detection of metallo-β-lactamase producing isolates by routine clinical microbiology laboratories. J Clin Microbiol 40, 2755–2759
  15. Walsh TR, Simm A, Gales AC, Biedenbach DJ, Jones RN, First Appearance of a mobile metallo-β-Lactamase in Latin America. J Antimicrob Chemother (in press)
  16. Yano H, Kuga A, Okamoto R, Kitasato H, Kobayashi T, Inoue M. Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem. Antimicrob Agents Chemother. 2001;45:1343–1348

PII: S0732-8893(02)00500-X

doi: 10.1016/S0732-8893(02)00500-X

Diagnostic Microbiology & Infectious Disease
Volume 45, Issue 1 , Pages 77-79 , January 2003

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