Diagnostic Microbiology & Infectious Disease
Volume 54, Issue 1 , Pages 79-82 , January 2006

High rates of erythromycin and clindamycin resistance among OBGYN isolates of group B Streptococcus

  • Linda P. DiPersio

      Affiliations

    • Falor Division of Surgical Research, Summa Health System, Akron, OH 44304, USA
  • ,
  • Joseph R. DiPersio

      Affiliations

    • Department of Pathology and Laboratory Medicine, Summa Health System, Akron, OH 44304, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-330-375-3667; fax: +1-330-375-4874.

Received 22 April 2005 ,Accepted 29 July 2005.

References 

  1. Andrews JI, Diekema DJ, Hunter SK, Rhomberg PR, Pfaller MA, Jones RN, et al. Group B streptococci causing neonatal bloodstream infection: antimicrobial susceptibility and serotyping results from SENTRY centers in the western hemisphere. Am. J. Obstet. Gynecol. 2000;183:859–862
  2. Arpin C, Daube H, Tessier F, Quentin C. Presence of mefA and mefE genes in Streptococcus agalactiae. Antimicrob. Agents Chemother. 1999;43:944–946
  3. Arpin C, Canron M-H, Noury P, Quentin C. Emergence of mefA and mefE genes in beta-haemolytic streptococci and pneumoncocci in France. J. Antimicrob. Chemother. 1999;44:133–134
  4. Clancy J, Petitpas J, Dib-Hajj F, Yuan W, Cronan M, Kamath AV, et al. Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes. Mol. Microbiol. 1996;22:867–879
  5. Daly MM, Doktor S, Flamm R, Shortridge D. Characterization and prevalence of MefA, MefE, and associated msr(D) gene in Streptococcus pneumoniae clinical isolates. J. Clin. Microbiol. 2004;42:3570–3574
  6. De Azavedo JCS, McGavin M, Duncan C, Low DE, McGeer A. Prevalence and mechanisms of macrolide resistance in invasive and noninvasive group B Streptococcus isolates from Ontario, Canada. Antimicrob. Agents Chemother. 2001;45:3504–3508
  7. De Mouy D, Cavallo J-D, Leclercq R, Fabre R, The AFORCOPI-BIO Network . Antibiotic susceptibility and mechanisms of erythromycin resistance in clinical isolates of Streptococus agalactiae: French multicenter study. Antimicrob. Agents Chemother. 2001;45:2400–2402
  8. Del Grosso M, Iannelli F, Messina C, Santagati M, Petrosillo N, Stefani S, et al. Macrolide efflux genes mef(A) and mef(E) are carried by different genetic elements in Streptococcus pneumoniae. J. Clin. Microbiol. 2002;40:774–778
  9. Diekema DJ, Andrews JI, Huynh H, Rhomberg PR, Doktor SR, Beyer J, et al. Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci. J. Clin. Microbiol. 2003;41:2659–2661
  10. DiPersio JR, File TM, Stevens DL, Gardner WG, Petropoulos G, Dinsa K. Spread of serious disease-producing M3 clones of group A Streptococcus among family members and health care workers. Clin. Infect. Dis. 1996;22:490–495
  11. Fitoussi F, Loukil C, Gross I, Clermont O, Mariani P, Bonacorsi S, et al. Mechanisms of macrolide resistance in clinical group B streptococci isolated in France. Antimicrob. Agents Chemother. 2001;45:1889–1891
  12. Hsueh P-R, Teng L-J, Lee L-N, Ho S-W, Yang P-C, Luh K-T. High incidence of erythromycin resistance among clinical isolates of Streptococcus agalactiae in Taiwan. Antimicrob. Agents Chemother. 2001;45:3205–3208
  13. Klugman KP, Capper T, Widdowson CA, Koornhof HJ, Moser W. Increased activity of 16-membered lactone ring macrolides against erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae: characterization of South African isolates. J. Antimicrob. Chemother. 1998;42:729–734
  14. Lewis JS, Jorgensen JH. Inducible clindamycin resistance in staphylococci: should clinicians and microbiologists be concerned?. Clin. Infect. Dis. 2005;40:280–285
  15. Lin FY, Azimi PH, Weisman LE, Philips JB, Regan J, Clark P, et al Antibiotic susceptibility profiles for group B streptococci isolated from neonates, 1995–1998. Clin. Infect. Dis. 2000;31:76–79
  16. Louie L, Goodfellow J, Mathieu P, Glatt A, Louie M, Simor AE. Rapid detection of methicillin-resistant staphylococci from blood culture bottles by using a multiplex PCR assay. J. Clin. Microbiol. 2002;40:2786–2790
  17. Marimon J, Valiente M, Montes D, Vicente D, Perez-Trallero E. Molecular epidemiology of M phenotype erythromycin-resistant group B streptococci (GBS) isolated from pregnant women in northern Spain (Abstract C2-803). In: 44th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC. 2004;
  18. Montanari MP, Mingoia M, Cochetti I, Varaldo PE. Phenotypes and genotypes of erythromycin-resistant pneumococci in Italy. J. Clin. Microbiol. 2003;41:428–431
  19. Murdoch DR, Reller LB. Antimicrobial susceptibilities of group B streptococci isolated from patients with invasive disease: 10 year perspective. Antimicrob. Agents Chemother. 2001;45:3623–3624
  20. National Committee for Clinical Laboratory Standards (NCCLS) . Performance standards for antimicrobial susceptibility testing; fourteenth informational supplement, M100-S14. Wayne, PA: National Committee for Clinical Laboratory Standards; 2004;
  21. Portillo A, Lantero M, Olarte I, Ruiz-Larrea F, Torres C. MLS resistance phenotypes and mechanisms in β-haemolytic group B, C and G Streptococcus isolates in La Rioja, Spain. J. Antimicrob. Chemother. 2001;47:115–116
  22. Poyart C, Jardy L, Quesne G, Berche P, Trieu-Cuot P. Genetic basis of antibiotic resistance in Streptococcus agalactiae strains isolated in a French hospital. Antimicrob. Agents Chemother. 2003;47:794–797
  23. Roberts MC, Sutcliffe J, Courvalin P, Jensen LB, Rood J, Seppala H. Nomenclature for macrolide and macrolide-lincosamide–streptogramin B resistance determinants. Antimicrob. Agents Chemother. 1999;43:2823–2830
  24. Schrag S, Gorwitz R, Fultz-Butts K, Schuchat A. Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC. MMWR Recomm. Rep. 2002;51:1–23
  25. Shortridge VD, Flamm RK, Ramer N, Beyer J, Tanaka SK. Novel mechanism of macrolide resistance in Streptococcus pneumoniae. Diagn. Microbiol. Infect. Dis. 1996;26:73–78
  26. Sutcliffe J, Grebe T, Tait-Kamradt A. Detection of erythromycin-resistant determinants by PCR. Antimicrob. Agents Chemother. 1996;40:2562–2566
  27. Sutcliffe J, Tait-Kamradt A, Wondrack L. Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system. Antimicrob. Agents Chemother. 1996;40:1817–1824
  28. Tait-Kamradt A, Clancy J, Cronan M, Dib-Hajj F, Wondrack L, Yuan W, et al. mefE is necessary for the erythromycin-resistant M phenotype in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 1997;41:2251–2255
  29. Weisblum B. Inducible resistance to macrolides, lincosamides, and streptogramin type B antibiotics: the resistance phenotype, its biological diversity, and structural elements that regulate expression—a review. J. Antimicrob. Chemother. 1985;16(Suppl. A):63–90
  30. York MK, Gibbs L, Perdreau-Remington F, Brooks GF. Characterization of antimicrobial resistance in Streptococcus pyogenes isolates from the San Francisco Bay area of Northern California. J. Clin. Microbiol. 1999;37:1727–1731

 This work was presented in part at the 2004 General Meeting, American Society for Microbiology, May 2004 (Abstract A-006).

PII: S0732-8893(05)00193-8

doi: 10.1016/j.diagmicrobio.2005.07.003

Diagnostic Microbiology & Infectious Disease
Volume 54, Issue 1 , Pages 79-82 , January 2006