Diagnostic Microbiology & Infectious Disease
Volume 62, Issue 4 , Pages 457-459 , December 2008

Investigation of qnr and aac(6′)-Ib-cr in Enterobacter cloacae isolates from Anhui Province, China

  • Zizhong Xiong

      Affiliations

    • Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Hefei 230022, China
    • School of Pharmacy, Anhui Medical University, Hefei 230032, China
    • ,
  • Peng Wang

      Affiliations

    • Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Hefei 230022, China
    • ,
  • Yanyan Wei

      Affiliations

    • Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Hefei 230022, China
    • ,
  • Hui Wang

      Affiliations

    • Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Hefei 230022, China
    • ,
  • Hongxia Cao

      Affiliations

    • Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Hefei 230022, China
    • ,
  • Huashan Huang

      Affiliations

    • Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Hefei 230022, China
    • ,
  • Jun Li

      Affiliations

    • School of Pharmacy, Anhui Medical University, Hefei 230032, China
    • Corresponding Author InformationCorresponding author. Tel.: +86-551-5161001; fax: +86-551-5161001.

Received 3 May 2008 ,Accepted 13 July 2008.

References 

  1. Clinical and Laboratory Standards Institute (CLSI) . Performance standards for antimicrobial susceptibility testing: 16th information supplement (M100-S16). Wayne, PA: Clinical and Laboratory Standards Institute; 2006;
  2. Gu Y, Zhang J, Yu Y, Zhou Z, Du X. Drug-resistant mechanisms and prevalence of Enterobacter cloacae resistant to multi-antibiotics. Chin. J. Nosocomiol. 2004;14:1321–1324
  3. Hata M, Suzuki M, Matsumoto M, Takahashi M, Sato K, Ibe S, et al. Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b. Antimicrob. Agents Chemother. 2005;49:803–805
  4. Hooper DC. Mechanism of action and resistance. Drug Resist. Updat. 1999;2:38–55
  5. Jacoby GA, Chow N, Waites KB. Prevalence of plasmid-mediated quinolone resistance. Antimicrob. Agents Chemother. 2003;47:559–562
  6. Jacoby GA, Walsh KE, Mills DM, Walker VJ, Oh H, Robicsek A, et al. qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob. Agents Chemother. 2006;50:1178–1182
  7. Klugman KP, Levin BR. One enzyme inactivates two antibiotics. Nat. Med. 2006;12:19–20
  8. Martinez-Martinez L, Pascual LA, Jacopy GA. Quinolone resistant from a transferable plasmid. Lancet. 1998;351:797–799
  9. Nordmann P, Poirel L. Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae. J. Antimicrob. Chemother. 2005;56:463–469
  10. Perichon B, Courvalin P, Galimand M. Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efllux in Escherichia coli. Antimicrob. Agents Chemother. 2007;51:2464–2469
  11. Robicsek A, Strahilevitz J, Jacoby GA, Mark M, Abbanat A, Park CH, et al. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat. Med. 2006;12:83–88
  12. Tran JH, Jacoby GA, Hooper DC. Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IV. Antimicrob. Agents Chemother. 2005;49:118–125
  13. Wang M, Tran JH, Jacoby GA, Zhang Y, Wang F, Hooper DC. Plasmid-mediated quinolone resistance in clinical of Escherichia coli from Shanghai, China. Antimicrob. Agents Chemother. 2003;47:2242–2248
  14. Yamane K, Wachino J, Suzuki S, Kimura K, Shibata N, Kato H, et al. New plasmid-mediated fluoroquinolone efllux pump, QepA, found in an Escherichia coli clinical isolate. Antimicrob. Agents Chemother. 2007;51:3354–3360

PII: S0732-8893(08)00342-8

doi: 10.1016/j.diagmicrobio.2008.07.010

Diagnostic Microbiology & Infectious Disease
Volume 62, Issue 4 , Pages 457-459 , December 2008

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