Volume 62, Issue 4 , Pages 460-463, December 2008
Interpretive categorical accuracy of fluoroquinolone reference broth microdilution MIC results when testing Streptococcus pneumoniae: selection of a surrogate testing agent☆
Abstract
The categorical agreement among MIC results for the fluoroquinolones tested (levofloxacin, moxifloxacin, gatifloxacin and gemifloxacin) was high (99.16–99.85%), and error rates were nil or very low when 1 compound was used as a surrogate for predicting susceptibility (not resistance) to another agent in the class. No error was observed when levofloxacin was selected as the group surrogate for pneumococcal testing.
Keywords: Streptococcus pneumoniae, Fluoroquinolones, Levofloxacin, Moxifloxacin, Gemifloxacin
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☆ Since the completion of this manuscript, the Clinical and Laboratory Standards Institute [CLSI (2009, in press) Performance standards for antimicrobial susceptibility testing; 19th informational supplement, M100-S19. CLSI, Wayne, PA] has approved and published these recommendations.
PII: S0732-8893(08)00396-9
doi:10.1016/j.diagmicrobio.2008.08.020
© 2008 Elsevier Inc. All rights reserved.
Volume 62, Issue 4 , Pages 460-463, December 2008
