Diagnostic Microbiology & Infectious Disease
Volume 62, Issue 4 , Pages 460-463, December 2008

Interpretive categorical accuracy of fluoroquinolone reference broth microdilution MIC results when testing Streptococcus pneumoniae: selection of a surrogate testing agent☆

  • Helio S. Sader

      Affiliations

    • JMI Laboratories, North Liberty, IA 52317, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-319-665-3370x200; fax: +1-319-655-3371.
    • ,
  • Laura M. Koeth

      Affiliations

    • Laboratory Specialists, Inc, Westlake, OH 44145, USA
    • ,
  • James A. Poupard

      Affiliations

    • Pharma Institute of Philadelphia, PA 19129, USA
    • ,
  • Ronald N. Jones

      Affiliations

    • JMI Laboratories, North Liberty, IA 52317, USA

Received 29 July 2008; accepted 27 August 2008. published online 06 November 2008.

Abstract 

The categorical agreement among MIC results for the fluoroquinolones tested (levofloxacin, moxifloxacin, gatifloxacin and gemifloxacin) was high (99.16–99.85%), and error rates were nil or very low when 1 compound was used as a surrogate for predicting susceptibility (not resistance) to another agent in the class. No error was observed when levofloxacin was selected as the group surrogate for pneumococcal testing.

Keywords: Streptococcus pneumoniae, Fluoroquinolones, Levofloxacin, Moxifloxacin, Gemifloxacin

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☆ Since the completion of this manuscript, the Clinical and Laboratory Standards Institute [CLSI (2009, in press) Performance standards for antimicrobial susceptibility testing; 19th informational supplement, M100-S19. CLSI, Wayne, PA] has approved and published these recommendations.

PII: S0732-8893(08)00396-9

doi:10.1016/j.diagmicrobio.2008.08.020

Diagnostic Microbiology & Infectious Disease
Volume 62, Issue 4 , Pages 460-463, December 2008

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