Diversity of the blaSHV genes

Received 25 November 2008; accepted 11 August 2009. published online 22 September 2009.

Abstract

We investigated the diversity of nucleotide sequences of 297 SHV-encoding genes, based on nucleotide synonymous mutations and the presence or absence of the nonsynonymous mutation T92A. The analysis of this diversity allowed us to develop and propose a classification to differentiate the nucleotide sequence variants of the blaSHV genes.

Keywords: Molecular diversity, Nucleotide sequence, Sequence variant, blaSHV gene

a Antibiotic Resistance Unit, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, 1649-016 Lisbon, Portugal

b Inserm, U-773, Faculté de Médecine D. Diderot, Université Paris 7, Paris, France

Corresponding author. Tel.: +351-217519246; fax: +351-217519246.

PII: S0732-8893(09)00334-4

doi:10.1016/j.diagmicrobio.2009.08.005

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