The Helicobacter pylori Mfd protein is important for antibiotic resistance and DNA repair
Received 30 June 2009; accepted 16 August 2009. published online 22 September 2009.
Abstract
A Helicobacter pylori mutant defective in a putative mfd gene was constructed and characterized. The mfd gene is required for DNA repair and is involved in DNA recombination processes. The mfd mutant strain displayed a greatly increased susceptibility to antibiotics, indicating that this gene plays a significant role in the antibiotic resistance of H. pylori strain J99.
aDivision of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
bAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
Corresponding authors. Jin-Ho Kim, MD, PhD, is to be contacted at Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea. Tel.: +82-2-3010-3185; fax: +82-2-476-0824. Jin-Yong Jeong, PhD, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea. Tel.: +82-2-3010-4105; fax: +82-2-3010-4182.
ABSTRACT