Diagnostic Microbiology & Infectious Disease
Volume 65, Issue 4 , Pages 454-456, December 2009

The Helicobacter pylori Mfd protein is important for antibiotic resistance and DNA repair

  • Gin Hyug Lee

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Jin-Yong Jeong

      Affiliations

    • Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • Corresponding Author InformationCorresponding authors. Jin-Ho Kim, MD, PhD, is to be contacted at Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea. Tel.: +82-2-3010-3185; fax: +82-2-476-0824. Jin-Yong Jeong, PhD, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea. Tel.: +82-2-3010-4105; fax: +82-2-3010-4182.
    • ,
  • Jun-Won Chung

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Won-Hee Nam

      Affiliations

    • Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Sun-Mi Lee

      Affiliations

    • Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Jhang-Ho Pak

      Affiliations

    • Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Kee Don Choi

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Ho June Song

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Hwoon-Yong Jung

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Jin-Ho Kim

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • Corresponding Author InformationCorresponding authors. Jin-Ho Kim, MD, PhD, is to be contacted at Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea. Tel.: +82-2-3010-3185; fax: +82-2-476-0824. Jin-Yong Jeong, PhD, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea. Tel.: +82-2-3010-4105; fax: +82-2-3010-4182.

Received 30 June 2009; accepted 16 August 2009. published online 22 September 2009.

Abstract 

A Helicobacter pylori mutant defective in a putative mfd gene was constructed and characterized. The mfd gene is required for DNA repair and is involved in DNA recombination processes. The mfd mutant strain displayed a greatly increased susceptibility to antibiotics, indicating that this gene plays a significant role in the antibiotic resistance of H. pylori strain J99.

Keywords: Helicobacter pylori, Antibiotic resistance, DNA repair

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PII: S0732-8893(09)00349-6

doi:10.1016/j.diagmicrobio.2009.08.007

Diagnostic Microbiology & Infectious Disease
Volume 65, Issue 4 , Pages 454-456, December 2009

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