Diagnostic Microbiology & Infectious Disease
Volume 65, Issue 4 , Pages 454-456 , December 2009

The Helicobacter pylori Mfd protein is important for antibiotic resistance and DNA repair

  • Gin Hyug Lee

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Jin-Yong Jeong

      Affiliations

    • Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • Corresponding Author InformationCorresponding authors. Jin-Ho Kim, MD, PhD, is to be contacted at Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea. Tel.: +82-2-3010-3185; fax: +82-2-476-0824. Jin-Yong Jeong, PhD, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea. Tel.: +82-2-3010-4105; fax: +82-2-3010-4182.
    • ,
  • Jun-Won Chung

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Won-Hee Nam

      Affiliations

    • Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Sun-Mi Lee

      Affiliations

    • Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Jhang-Ho Pak

      Affiliations

    • Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Kee Don Choi

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Ho June Song

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Hwoon-Yong Jung

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • ,
  • Jin-Ho Kim

      Affiliations

    • Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
    • Corresponding Author InformationCorresponding authors. Jin-Ho Kim, MD, PhD, is to be contacted at Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea. Tel.: +82-2-3010-3185; fax: +82-2-476-0824. Jin-Yong Jeong, PhD, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea. Tel.: +82-2-3010-4105; fax: +82-2-3010-4182.

Received 30 June 2009 ,Accepted 16 August 2009.

References 

  1. Alm RA, Ling LS, Moir DT, King BL, Brown ED, Doig PC, et al. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature. 1999;397:176–180
  2. Clinical and Laboratory Standards Institute . Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard—M7-A7. Wayne, PA: CLSI; 2006;
  3. George DL, Witkin EM. Slow excision repair in an mfd mutant of Escherichia coli B/r. Mol. Gen. Genet. 1974;133:283–291
  4. George DL, Witkin EM. Ultraviolet light-induced responses of an mfd mutant of Escherichia coli B/r having a slow rate of dimer excision. Mutat. Res. 1975;28:347–354
  5. Han J, Sahin O, Barton YW, Zhang Q. Key role of Mfd in the development of fluoroquinolone resistance in Campylobacter jejuni. PLoS Pathog. 2008;e1000083:4
  6. Jeong JY, Mukhopadhyay AK, Dailidiene D, Wang Y, Velapatiño B, Gilman RH, et al. Sequential inactivation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes causes moderate and high-level metronidazole resistance in Helicobacter pylori. J. Bacteriol. 2000;182:5082–5090
  7. Kusters JG, van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin. Microbiol. Rev. 2006;19:449–490
  8. Selby CP, Sancar A. Molecular mechanism of transcription-repair coupling. Science. 1993;260:53–58
  9. Selby CP, Sancar A. Mechanisms of transcription-repair coupling and mutation frequency decline. Microbiol. Mol. Biol. Rev. 1994;58:317–329

PII: S0732-8893(09)00349-6

doi: 10.1016/j.diagmicrobio.2009.08.007

Diagnostic Microbiology & Infectious Disease
Volume 65, Issue 4 , Pages 454-456 , December 2009

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