Diagnostic Microbiology & Infectious Disease
Volume 65, Issue 4 , Pages 447-449, December 2009

In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment

  • Wonkeun Song

      Affiliations

    • Department of Laboratory Medicine, Hallym University College of Medicine, 120-950 Seoul, Republic of Korea
    • ,
  • Borum Suh

      Affiliations

    • Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, 120-752 Seoul, Republic of Korea
    • ,
  • Jun Yong Choi

      Affiliations

    • Department of Internal Medicine, Yonsei University College of Medicine, 120-752 Seoul, Republic of Korea
    • ,
  • Seok Hoon Jeong

      Affiliations

    • Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, 120-752 Seoul, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82-2-2228-2448; fax: +82-2-313-0908.
    • ,
  • Eun Hee Jeon

      Affiliations

    • Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, 120-752 Seoul, Republic of Korea
    • ,
  • Young Ki Lee

      Affiliations

    • Department of Internal Medicine, Hallym University College of Medicine, 120-950 Seoul, Republic of Korea
    • ,
  • Seong Geun Hong

      Affiliations

    • Department of Laboratory Medicine, CHA University School of Medicine, 463-712 Sungnam, Republic of Korea
    • ,
  • Kyungwon Lee

      Affiliations

    • Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, 120-752 Seoul, Republic of Korea

Received 11 June 2009; accepted 17 August 2009. published online 22 September 2009.

Abstract 

We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC β-lactamase.

Keywords: OmpK35, OmpK36, DHA-1, Carbapenems, IS5

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PII: S0732-8893(09)00352-6

doi:10.1016/j.diagmicrobio.2009.08.010

Diagnostic Microbiology & Infectious Disease
Volume 65, Issue 4 , Pages 447-449, December 2009

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