In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment
Received 11 June 2009; accepted 17 August 2009. published online 22 September 2009.
Abstract
We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC β-lactamase.
aDepartment of Laboratory Medicine, Hallym University College of Medicine, 120-950 Seoul, Republic of Korea
bDepartment of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, 120-752 Seoul, Republic of Korea
cDepartment of Internal Medicine, Yonsei University College of Medicine, 120-752 Seoul, Republic of Korea
dDepartment of Internal Medicine, Hallym University College of Medicine, 120-950 Seoul, Republic of Korea
eDepartment of Laboratory Medicine, CHA University School of Medicine, 463-712 Sungnam, Republic of Korea