Diagnostic Microbiology & Infectious Disease
Volume 65, Issue 4 , Pages 379-383, December 2009

Characterization of plasmids encoding CMY-2 AmpC β-lactamases from Escherichia coli in Canadian intensive care units☆☆☆

  • Patricia J. Baudry

      Affiliations

    • Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada R3A 1R9
    • Department of Clinical Microbiology, Health Sciences Centre, Winnipeg, Canada R3A 1R9
    • Corresponding Author InformationCorresponding author. Department of Clinical Microbiology, Health Sciences Centre, Winnipeg, Manitoba, Canada R3A 1R9. Tel.: +1-204-787-4684; fax: +1-204-787-4699.
    • ,
  • Laura Mataseje

      Affiliations

    • Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada R3A 1R9
    • National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada R3E 3R2
    • ,
  • George G. Zhanel

      Affiliations

    • Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada R3A 1R9
    • Department of Clinical Microbiology, Health Sciences Centre, Winnipeg, Canada R3A 1R9
    • ,
  • Daryl J. Hoban

      Affiliations

    • Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada R3A 1R9
    • Department of Clinical Microbiology, Health Sciences Centre, Winnipeg, Canada R3A 1R9
    • ,
  • Michael R. Mulvey

      Affiliations

    • Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada R3A 1R9
    • National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada R3E 3R2

Received 14 May 2009; accepted 14 August 2009. published online 24 September 2009.

Abstract 

The dissemination of CMY-2 AmpC β-lactamases among Escherichia coli in Canadian intensive care units occurs through a combination of clonal spread of virulent strains and the horizontal transfer of genetically similar IncI1, IncA/C, and IncK/B plasmids.

Keywords: Escherichia coli, CMY-2 AmpC β-Lactamase, Plasmids

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☆ This article was presented in part at the American Society for Microbiology 108th General Meeting (2008) in Boston, MA.

☆☆ Patricia Baudry is supported by the Winnipeg Health Sciences Centre Department of Research, the Winnipeg Health Sciences Centre Foundation, and the Manitoba Health Research Council. This research is funded in part by Abott, Bayer Canada, Bristol-Myers Squibb, Janssen-Ortho, Merck Frosst, Sanofi-Aventis, and Wyeth.

PII: S0732-8893(09)00353-8

doi:10.1016/j.diagmicrobio.2009.08.011

Diagnostic Microbiology & Infectious Disease
Volume 65, Issue 4 , Pages 379-383, December 2009

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