Diagnostic Microbiology & Infectious Disease
Volume 66, Issue 2 , Pages 222-224, February 2010

Genotypes, superantigen gene profiles, and presence of exfoliative toxin genes in clinical methicillin-susceptible Staphylococcus aureus isolates

  • Marijke J.C.A. van Trijp

      Affiliations

    • Laboratory for Medical Microbiology, Maasstad Hospital, 3078 HT Rotterdam, The Netherlands
    • Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center, 3015 CE Rotterdam, The Netherlands
    • Corresponding Author InformationCorresponding author. Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center, 3015 CE Rotterdam, The Netherlands. Tel.: +31-10-7033510; fax: +31-10-7033875.
    • ,
  • Damian C. Melles

      Affiliations

    • Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center, 3015 CE Rotterdam, The Netherlands
    • ,
  • Susan V. Snijders

      Affiliations

    • Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center, 3015 CE Rotterdam, The Netherlands
    • ,
  • Heiman F.L. Wertheim

      Affiliations

    • Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center, 3015 CE Rotterdam, The Netherlands
    • ,
  • Henri A. Verbrugh

      Affiliations

    • Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center, 3015 CE Rotterdam, The Netherlands
    • ,
  • Alex van Belkum

      Affiliations

    • Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center, 3015 CE Rotterdam, The Netherlands
    • ,
  • Willem J. van Wamel

      Affiliations

    • Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center, 3015 CE Rotterdam, The Netherlands

Received 1 May 2009; accepted 23 August 2009. published online 15 October 2009.

Abstract 

We compared genotype and virulence gene profiles for strains from carriers with autologous invasive infection (n = 56), nasal isolates from matched carriers (n = 108), and invasive strains from noncarriers (n = 34). Superantigen gene profiles and presence of exfoliative toxin genes A and D were associated with clonal complex rather than with invasive disease.

Keywords: Staphylococcus aureus, Superantigen genes, Bacteraemia, Clonal complexes

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PII: S0732-8893(09)00360-5

doi:10.1016/j.diagmicrobio.2009.08.021

Diagnostic Microbiology & Infectious Disease
Volume 66, Issue 2 , Pages 222-224, February 2010

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