Diagnostic Microbiology & Infectious Disease
Volume 66, Issue 2 , Pages 207-209, February 2010

Emergence of multidrug-resistant Salmonella enterica serovar Typhi with reduced susceptibility to fluoroquinolones in Cambodia☆

  • Matthew R. Kasper

      Affiliations

    • US Naval Medical Research Unit No. 2, Jakarta, Indonesia 10560
    • Corresponding Author InformationCorresponding author. US Embassy Jakarta, FPO AP 96520, Indonesia. Tel.: +62-21-421-4457; fax: +62-21-428-73658.
    • ,
  • Buth Sokhal

      Affiliations

    • National Institute of Public Health, Ministry of Health, Phnom Penh, Cambodia 12152
    • ,
  • Patrick J. Blair

      Affiliations

    • US Naval Medical Research Unit No. 2, Jakarta, Indonesia 10560
    • ,
  • Thomas F. Wierzba

      Affiliations

    • US Naval Medical Research Unit No. 2, Phnom Penh, Cambodia 12152
    • ,
  • Shannon D. Putnam

      Affiliations

    • US Naval Medical Research Unit No. 2, Jakarta, Indonesia 10560

Received 29 July 2009; accepted 2 September 2009. published online 05 October 2009.

Abstract 

From December 2006 to April 2009, we conducted an etiology study among Cambodian patients presenting with acute fever of unknown origin. Salmonella enterica serovar Typhi was detected in 0.9% (41/4985) blood cultures. Antimicrobial susceptibility testing showed decreased susceptibility to ampicillin (56% resistant; MIC90, >256 μg/mL), chloramphenicol (56% resistant; MIC90, >256 μg/mL), trimethoprim/sulfamethoxazole (56% resistant; MIC90, >256 μg/mL), nalidixic acid (81% resistant; MIC90, not defined), ciprofloxacin (0% resistant; MIC90, 0.5 μg/mL), and ceftriaxone (0% resistant; MIC90, 0.094 μg/mL). Multidrug resistance, defined as antimicrobial resistance to ampicillin, chloramphenicol, and trimethoprim/sulfamethoxazole, was found in 56% of the isolates, and 80% had reduced susceptibility to ciprofloxacin (defined as MIC ≥0.12 μg/mL).

Keywords: Cambodia, Typhoid fever, Salmonella enterica serovar Typhi

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☆ Disclosure: Views expressed in this article are those of the authors and do not reflect the official policy of the government of Cambodia, Cambodian Ministry of Health, Cambodian NIPH, the US Department of Defense, Department of the Navy, or US NAMRU2 Phnom Penh, Cambodia.

PII: S0732-8893(09)00365-4

doi:10.1016/j.diagmicrobio.2009.09.002

Diagnostic Microbiology & Infectious Disease
Volume 66, Issue 2 , Pages 207-209, February 2010

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