Diagnostic Microbiology & Infectious Disease
Volume 66, Issue 2 , Pages 207-209 , February 2010

Emergence of multidrug-resistant Salmonella enterica serovar Typhi with reduced susceptibility to fluoroquinolones in Cambodia

  • Matthew R. Kasper

      Affiliations

    • US Naval Medical Research Unit No. 2, Jakarta, Indonesia 10560
    • Corresponding Author InformationCorresponding author. US Embassy Jakarta, FPO AP 96520, Indonesia. Tel.: +62-21-421-4457; fax: +62-21-428-73658.
    • ,
  • Buth Sokhal

      Affiliations

    • National Institute of Public Health, Ministry of Health, Phnom Penh, Cambodia 12152
    • ,
  • Patrick J. Blair

      Affiliations

    • US Naval Medical Research Unit No. 2, Jakarta, Indonesia 10560
    • ,
  • Thomas F. Wierzba

      Affiliations

    • US Naval Medical Research Unit No. 2, Phnom Penh, Cambodia 12152
    • ,
  • Shannon D. Putnam

      Affiliations

    • US Naval Medical Research Unit No. 2, Jakarta, Indonesia 10560

Received 29 July 2009 ,Accepted 2 September 2009.

References 

  1. Chau TT, Campbell JI, Galindo CM, Van Minh Hoang N, Diep TS, Nga TT, et al. Antimicrobial drug resistance of Salmonella enterica serovar Typhi in Asia and molecular mechanism of reduced susceptibility to the fluoroquinolones. Antimicrob. Agents Chemother. 2007;51:4315–4323
  2. Clinical and Laboratory Standards Institute (CLSI) . Performance standards for antimicrobial disk susceptibility tests (M02-A10). Wayne, PA: CLSI; 2009;
  3. Clinical and Laboratory Standards Institute (CLSI) . Performance standards for antimicrobial susceptibility testing. In: 19th informational supplement (M100-S19). Wayne, PA: CLSI. 2009;
  4. Crump JA, Youssef FG, Luby SP, Wasfy MO, Rangel JM, Taalat M, et al. Estimating the incidence of typhoid fever and other febrile illnesses in developing countries. Emerg. Infect. Dis. 2003;9:539–544
  5. Crump JA, Luby SP, Mintz ED. The global burden of typhoid fever. Bull. World Health Org. 2004;82:346–353
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  7. Hakanen A, Kotilainen P, Jalava J, Siitonen A, Huovinen P. Detection of decreased fluoroquinolone susceptibility in Salmonellas and validation of nalidixic acid screening test. J. Clin. Microbiol. 1999;37:3572–3577
  8. Hakanen AJ, Lindgren M, Huovinen P, Jalava J, Siitonen A, Kotilainen P. New quinolone resistance phenomenon in Salmonella enterica: nalidixic acid-susceptible isolates with reduced fluoroquinolone susceptibility. J. Clin. Microbiol. 2005;43:5775–5778
  9. Mirza SH, Beeching NJ, Hart CA. Multi-drug resistant typhoid: a global problem. J. Med. Microbiol. 1996;44:317–319
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  11. Rupali P, Abraham OC, Jesudason MV, John TJ, Zachariah A, Sivaram S, et al. Treatment failure in typhoid fever with ciprofloxacin susceptible Salmonella enterica serotype Typhi. Diagn. Microbiol. Infect. Dis. 2004;49:1–3
  12. Threlfall EJ, Ward LR, Skinner JA, Smith HR, Lacey S. Ciprofloxacin-resistant Salmonella typhi and treatment failure. Lancet. 1999;353:1590–1591
  13. Threlfall EJ, Skinner JA, Ward LR. Detection of decreased in vitro susceptibility to ciprofloxacin in Salmonella enterica serotypes Typhi and Paratyphi A. J. Antimicrob. Chemother. 2001;48:740–741
  14. Threlfall EJ, Fisher IS, Berghold C, Gerner-Smidt P, Tschape H, Cormican M, et al. Trends in antimicrobial drug resistance in Salmonella enterica serotypes Typhi and Paratyphi A isolated in Europe, 1999–2001. Int. J. Antimicrob. Agents. 2003;22:487–491
  15. Wain J, Hoa NT, Chinh NT, Vinh H, Everett MJ, Diep TS, et al. Quinolone-resistant Salmonella typhi in Viet Nam: molecular basis of resistance and clinical response to treatment. Clin. Infect. Dis. 1997;25:1404–1410

☆ Disclosure: Views expressed in this article are those of the authors and do not reflect the official policy of the government of Cambodia, Cambodian Ministry of Health, Cambodian NIPH, the US Department of Defense, Department of the Navy, or US NAMRU2 Phnom Penh, Cambodia.

PII: S0732-8893(09)00365-4

doi: 10.1016/j.diagmicrobio.2009.09.002

Diagnostic Microbiology & Infectious Disease
Volume 66, Issue 2 , Pages 207-209 , February 2010

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