A novel OXA-10–like β-lactamase is present in different Enterobacteriaceae☆

Received 20 May 2009; accepted 9 September 2009. published online 16 October 2009.

Abstract

OXA 101, a novel OXA-10 like enzyme, was found forming part of a class 1 integron located in a conjugative plasmid in three different species of Enterobacteriaceae. This β-lactamase is related to OXA-35 and OXA-56 and displays a narrow substrate hydrolysis profile.

Keywords: OXA-10 like, Gene cassette, Dissemination

a Cátedra de Microbiología General, Facultad de Bioquímica y Cs. Biológicas, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina

b Centro de Biología Molecular “Severo Ochoa”, CSIC-UAM, Campus de Cantoblanco, 28049 Madrid, Spain

c Cátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina

Corresponding author. Tel.: +54-11-49648285; fax: +54-11-45083645.

☆ This manuscript was presented, in part, at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 2007.

PII: S0732-8893(09)00375-7

doi:10.1016/j.diagmicrobio.2009.09.010

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