Diagnostic Microbiology & Infectious Disease
Volume 66, Issue 3 , Pages 318-321 , March 2010

Molecular identification of phaeohyphomycosis due to Alternaria infectoria in a patient with acute myeloid leukemia—a case report

  • T. Ronan Leahy

      Affiliations

    • Genomic Research Laboratory, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James's Hospital, James's St, Dublin, Ireland
    • Corresponding Author InformationCorresponding author. Tel.: +353-1-6751984; fax: +1-416-813-8404.
    • Formerly affiliated with Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Canada.
    • ,
  • Angela S. Punnett

      Affiliations

    • Division of Haematology, Oncology and Bone Marrow Transplant, Department of Paediatrics, The Hospital for Sick Children, Toronto
    • ,
  • Susan E. Richardson

      Affiliations

    • Division of Microbiology, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto
    • ,
  • Farhad Gharabaghi

      Affiliations

    • Division of Microbiology, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto
    • ,
  • Anupma Wadhwa

      Affiliations

    • Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, Toronto

Received 28 June 2009 ,Accepted 30 September 2009.

References 

  1. Al-Rezqi A, Hawkes M, et al. Invasive mold infections in iatrogenically immunocompromised children: an eight-yr review. Pediatr. Transplant. 2008;
  2. Ben-Ami R, Lewis R, et al. Phaeohyphomycosis in a tertiary care cancer center. Clin. Infect. Dis. 2009;48:1033–1041
  3. Collier L, Balows A, et al. Topley and Wilson's microbiology and microbial infections. London: Arnold; 1998;
  4. de Hoog GS, Horre R, et al. Molecular taxonomy of the Alternaria and Ulocladium species from humans and their identification in the routine laboratory. Mycoses. 2002;45:259–276
  5. Espinel-Ingroff A. Comparison of in vitro activities of the new triazole SCH56592 and the echinocandins MK-0991 (L-743,872) and LY303366 against opportunistic filamentous and dimorphic fungi and yeasts.. J. Clin. Microbiol. 1998;36:2950–2956
  6. Laich F, Alcoba-Florez J, et al. Molecular characterisation of Alternaria alternata causing ocular infection: detection of IGS-RFLP intraspecific polymorphism.. Med. Mycol. 2008;46:615–619
  7. Lo Cascio G, Ligozzi M, et al. Utility of molecular identification in opportunistic mycotic infections: a case of cutaneous Alternaria infectoria infection in a cardiac transplant recipient.. J. Clin. Microbiol. 2004;42:5334–5336
  8. McGinnis MR, Pasarell L. In vitro testing of susceptibilities of filamentous ascomycetes to voriconazole, itraconazole, and amphotericin B, with consideration of phylogenetic implications.. J. Clin. Microbiol. 1998;36:2353–2355
  9. Neofytos D, Horn D, et al. Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry.. Clin. Infect. Dis. 2009;48:265–273
  10. Pastor FJ, Guarro J. Alternaria infections: laboratory diagnosis and relevant clinical features.. Clin. Microbiol. Infect. 2008;14:734–746
  11. Pritchard RC, Muir DB. Black fungi: a survey of dematiaceous Hyphomycetes from clinical specimens identified over a five year period in a reference laboratory.. Pathology. 1987;19:281–284
  12. Radford SA, Johnson EM, et al. In vitro studies of activity of voriconazole (UK-104,496), a new triazole antifungal agent, against emerging and less-common mold pathogens.. Antimicrob. Agents. Chemother. 1997;41:841–843
  13. Rickerts V, Mousset S, et al. Comparison of histopathological analysis, culture, and polymerase chain reaction assays to detect invasive mold infections from biopsy specimens.. Clin. Infect. Dis. 2007;44:1078–1083
  14. Sanche S, Sutton D, et al. Dematiaceous fungi. In:  Anaissie E,  McGinnis M,  Pfaller M editor. Clinical mycology. Philadelphia, PA: Elsevier Science; 2003;p. 325–351
  15. Wildfeuer A, Seidl HP, et al. In vitro evaluation of voriconazole against clinical isolates of yeasts, moulds and dermatophytes in comparison with itraconazole, ketoconazole, amphotericin B and griseofulvin.. Mycoses. 1998;41:309–319

PII: S0732-8893(09)00405-2

doi: 10.1016/j.diagmicrobio.2009.09.019

Diagnostic Microbiology & Infectious Disease
Volume 66, Issue 3 , Pages 318-321 , March 2010

Article Tools

* Image Usage & Resolution