Diagnostic Microbiology & Infectious Disease
Volume 66, Issue 3 , Pages 292-300, March 2010

Trends in antibiotic susceptibility of bloodstream pathogens in hospitalized patients in France, 1996 to 2007☆

  • Jean-Winoc Decousser

      Affiliations

    • Department of Bacteriology and Infection Control, AP-HP, Centre Hospitalier Universitaire Antoine Béclère, 92141 Clamart, France
    • Corresponding Author InformationCorresponding author. Tel.: +33-1-45-37-42-97; fax: +33-1-45-37-48-45.
    • Contributed equally to this article.
    • ,
  • Brigitte Lamy

      Affiliations

    • Department of Biology, Centre Hospitalier du Bassin de Thau, 34200 Sète, France
    • Contributed equally to this article.
    • ,
  • Patrick Pina

      Affiliations

    • Department of Internal Medecin B, Hôpital de Plaisir Grignon, 78310 Plaisir, France
    • ,
  • Pierre Yves Allouch

      Affiliations

    • Department of Infection Control, Centre Hospitalier de Versailles André Mignot, 78157 Le Chesnay, France
    • ,
  • the Collège de Bactériologie Virologie Hygiène study Group (ColBVH)

      Affiliations

    • The ColBVH study group participants are listed in the Acknowledgements.

Received 19 June 2009; accepted 7 October 2009. published online 11 November 2009.

Abstract 

Nationwide surveys of antimicrobial susceptibility of bacteria isolated from bloodstream infections are required to fit empiric therapy to recent trends and detect emerging resistance. We report the results of a French national prospective survey based on the College of Bacteriology–Virology and Hygiene study group network performed each October during the 1996 to 2007 period, with focus on Enterobacteriaceae (7708 isolates) and Staphylococcus aureus (2271 isolates). The most relevant antimicrobial susceptibilities trends were i) a decrease in fluoroquinolones susceptibility among Enterobacteriaceae (96–90%, P < 0.0001) and Escherichia coli isolates (98–89%, P < 0.0001), respectively, ii) the slight but significant decrease in cefotaxime susceptibility among E. coli (P = 0.016), and iii) the significant increase in gentamicin susceptibility among S. aureus strains (P = 0.016). This survey reports antibiotic susceptibility of bloodstream pathogens in France. The empiric use of fluoroquinolones in severe infections should be cautiously monitored by thorough clinical and microbiologic follow-up.

Keywords: Bloodstream infection, France, Antimicrobial susceptibility, Trends

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☆ No funding of any kind has been received for this work.

PII: S0732-8893(09)00417-9

doi:10.1016/j.diagmicrobio.2009.10.007

Diagnostic Microbiology & Infectious Disease
Volume 66, Issue 3 , Pages 292-300, March 2010

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