Diagnostic Microbiology & Infectious Disease
Volume 66, Issue 3 , Pages 336-338, March 2010

Antimicrobial susceptibility of multidrug-resistant Streptococcus pneumoniae strains with penicillin MICs of 8 to 32 mg/L

Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundación Jiménez Díaz-Capio, 28040 Madrid, Spain

Received 23 July 2009; accepted 22 October 2009. published online 27 November 2009.

Abstract 

The in vitro activity of 22 antibiotics (including novobiocin) and β-lactam/gentamicin combinations was assessed against 11 multidrug-resistant pneumococcal strains. Among orally administered drugs, only telithromycin, levofloxacin, and linezolid were active against all isolates, but their use is not indicated in pediatrics. Novobiocin could be a potential therapeutic alternative.

Keywords: Streptococcus pneumoniae, antibiotic resistance

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PII: S0732-8893(09)00425-8

doi:10.1016/j.diagmicrobio.2009.10.015

Diagnostic Microbiology & Infectious Disease
Volume 66, Issue 3 , Pages 336-338, March 2010

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