Diagnostic Microbiology & Infectious Disease
Volume 67, Issue 2 , Pages 188-190 , June 2010

Carriage of qnrA1 and qnrB2, blaCTX-M15, and complex class 1 integron in a clinical multiresistant Citrobacter freundii isolate

  • Sónia Ferreira

      Affiliations

    • CESAM and Biology Department, University of Aveiro, 3810-193 Aveiro, Portugal
    • ,
  • Ana Paradela

      Affiliations

    • CESAM and Biology Department, University of Aveiro, 3810-193 Aveiro, Portugal
    • ,
  • Jorge Velez

      Affiliations

    • Hospital Infante D. Pedro EPE, 3810-096 Aveiro, Portugal
    • ,
  • Elmano Ramalheira

      Affiliations

    • Hospital Infante D. Pedro EPE, 3810-096 Aveiro, Portugal
    • ,
  • Timothy R. Walsh

      Affiliations

    • Department of Medical Microbiology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    • ,
  • Sónia Mendo

      Affiliations

    • CESAM and Biology Department, University of Aveiro, 3810-193 Aveiro, Portugal
    • Corresponding Author InformationCorresponding author. CESAM and Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193, Aveiro, Portugal. Tel.: +351 234370970; fax: +351 234372587.

Received 11 November 2009 ,Accepted 7 January 2010.

References 

  1. Andriole VT. The quinolones: past, present, and future. Clin. Infect. Dis. 2005;41:S113–S119
  2. Cavaco LM, Hansen DS, Friis-Moller A, Aarestrup FM, Hasman H, Frimodt-Moller N. First detection of plasmid-mediated quinolone resistance (qnrA and qnrS) in Escherichia coli strains isolated from humans in Scandinavia. J. Antimicrob. Chemother. 2007;59:804–805
  3. Clinical and Laboratory Standards Institute (CLSI) . Performance standards for antimicrobial susceptibility testing: 17th informational supplement (M100-S17). Wayne, PA: CLSI; 2007;
  4. Ferreira S, Toleman M, Paradela A, Pereira A, Ramalheira E, Walsh T, et al. First Description of Klebsiella pneumoniae isolates carrying both qnrA and qnrB genes in Aveiro, Portugal. In: 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy and the Infectious Diseases Society of America. 2008;P-C2-3902
  5. Jacoby GA, Walsh KE, Mills DM, Walker VJ, Oh H, Robicsek A, et al. qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob. Agents Chemother. 2006;50:1178–1182
  6. Machado E, Canton R, Baquero F, Galan J-C, Rollan A, Peixe L, et al. Integron content of extended-spectrum-{beta}-lactamase–producing Escherichia coli strains over 12 years in a single hospital in Madrid, Spain. Antimicrob. Agents Chemother. 2005;49:1823–1829
  7. Moura A, Henriques I, Ribeiro R, Correia A. Prevalence and characterization of integrons from bacteria isolated from a slaughterhouse wastewater treatment plant. J. Antimicrob. Chemother. 2007;60:1243–1250
  8. Nordmann P, Poirel L. Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae. J. Clin. Microbiol. 2005;56:463–469
  9. Park Y-J, Yu JK, Lee S, Oh E-J, Woo G-J. Prevalence and diversity of qnr alleles in AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Serratia marcescens: a multicentre study from Korea. J. Antimicrob. Chemother. 2007;60:868–871
  10. Robicsek A, Strahilevitz J, Sahm DF, Jacoby GA, Hooper DC. qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States. Antimicrob. Agents Chemother. 2006;50:2872–2874
  11. Toleman MA, Vinodh H, Sekar U, Kamat V, Walsh TR. blaVIM-2–harboring integrons isolated in India, Russia, and the United States arise from an ancestral class 1 integron predating the formation of the 3′ conserved sequence. Antimicrob. Agents Chemother. 2007;51:2636–2638

☆ Part of this work was presented at the 19th European Conference of Clinical Microbiology and Infectious Diseases, Helsinki, Finland, 2009.

☆☆ Sónia Ferreira was funded by a fellowship SFRH/BDE/15573/2005 from Fundação para a Ciência e a Tecnologia de Portugal and by Hospital Infante D. Pedro EPE, Aveiro, Portugal.

PII: S0732-8893(10)00007-6

doi: 10.1016/j.diagmicrobio.2010.01.003

Diagnostic Microbiology & Infectious Disease
Volume 67, Issue 2 , Pages 188-190 , June 2010

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