Diagnostic Microbiology & Infectious Disease
Volume 67, Issue 2 , Pages 191-197, June 2010

Activity of doripenem with and without levofloxacin, amikacin, and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii

  • Glenn A. Pankuch

      Affiliations

    • Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    • ,
  • Harald Seifert

      Affiliations

    • Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
    • ,
  • Peter C. Appelbaum

      Affiliations

    • Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-717-531-5113; fax: +1-717-531-7953.

Received 11 December 2009; accepted 10 January 2010. published online 25 March 2010.

Abstract 

At 24 h, sub-MIC doripenem and levofloxacin showed synergy against 21 of 25 Pseudomonas aeruginosa strains, sub-MIC doripenem and amikacin against 22 isolates, and sub-MIC doripenem and colistin against 19 isolates. Of 25 Acinetobacter baumannii strains, sub-MIC doripenem and levofloxacin showed synergy against 11 strains at 24 h, sub-MIC doripenem and amikacin against 24 strains, and sub-MIC doripenem and colistin against all isolates.

Keywords: Doripenem, Time–kill synergy, Pseudomonas aeruginosa, Acinetobacter baumannii

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PII: S0732-8893(10)00008-8

doi:10.1016/j.diagmicrobio.2010.01.004

Diagnostic Microbiology & Infectious Disease
Volume 67, Issue 2 , Pages 191-197, June 2010

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