Diagnostic Microbiology & Infectious Disease
Volume 67, Issue 2 , Pages 180-184 , June 2010

Carbapenem-resistant Klebsiella pneumoniae bacteremia: factors correlated with clinical and microbiologic outcomes

  • May Nguyen

      Affiliations

    • Department of Pharmacy, NewYork-Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA
    • ,
  • Gregory A. Eschenauer

      Affiliations

    • Department of Pharmacy, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    • Corresponding Author InformationCorresponding author. Falk Medical Building, Suite 3A, 3601 Fifth Avenue, Pittsburgh, PA 15213. Tel.: +1-330-414-0563; fax: +1-412-648-6399.
    • ,
  • Monique Bryan

      Affiliations

    • Department of Pharmacy, NewYork-Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA
    • ,
  • Kelly O'Neil

      Affiliations

    • Department of Pharmacy, NewYork-Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA
    • ,
  • E. Yoko Furuya

      Affiliations

    • Department of Medicine, NewYork-Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA
    • ,
  • Phyllis Della-Latta

      Affiliations

    • Department of Pathology, NewYork-Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA
    • ,
  • Christine J. Kubin

      Affiliations

    • Department of Pharmacy, NewYork-Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA

Received 14 December 2009 ,Accepted 2 February 2010.

References 

  1. Bradford PA, Bratu S, Urban C, Visalli M, Mariano N, Landman D, et al. Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 β-lactamases in New York City. Clin. Infect. Dis. 2004;39:55–60
  2. Bratu S, Landman D, Haag R, Recco R, Eramo A, Alam M, et al. Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium. Arch. Intern. Med. 2005;165:1430–1435
  3. Bratu S, Mooty M, Nichani S, Landman D, Gullans C, Pettinato B, et al. Emergence of KPC-possessing Klebsiella pneumoniae in Brooklyn, New York: epidemiology and recommendations for detection.. Antimicrob. Agents Chemother. 2005;49:3018–3020
  4. Bratu S, Tolaney P, Karumudi U, Quale J, Mooty M, Nichani S, et al. Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agents.. J. Antimicrob. Chemother. 2005;56:128–132
  5. Gootz TD, Lescoe MK, Dib-Hajj F, Dougherty BA, He W, Della-Latta P, et al. Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. Antimicrob. Agents Chemother. 2009;53:1998–2004
  6. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit. Care Med. 1995;13:818–829
  7. Munoz-Price LS, Zembower T, Schreckenberger P, Harton L, Mohapatra S, Baig MO, et al. Tigecycline (tg) vs. colistin (co) for the treatment of multidrug resistant (mdr) Acinetobacter baumannii (ab) blood stream infection (bsi). In: Abstracts of the 45th Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL. Washington, DC, USA: American Society for Microbiology; 2007;Abstract K-389
  8. Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect. Dis. 2009;9:228–236
  9. Patel G, Huprikar S, Factor SH, Jenkins SG, Calfee DP. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect. Control. Hosp. Epidemiol. 2008;29:1099–1106
  10. Peleg AY, Potoski BA, Rea R, Adams J, Sethi J, Capitano B, et al. Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary report. J. Antimicrob. Chemother. 2007;59:128–131
  11. Thom KA, Shardell MD, Osih RB, Schweizer ML, Furuno JP, Perencevich EN, et al. Controlling for severity of illness in outcome studies involving infectious diseases: impact of measurement at different time points. Infect. Control. Hosp. Epidemiol. 2008;29:1048–1053
  12. Yigit H, Queenan AM, Anderson GJ, Domenech-Sanchez A, Biddle JW, Steward CD, et al. Novel carbapenem-hydrolyzing β-lactamase, KPC-1, from a carbapenem resistant strain of Klebsiella pneumoniae. Antimicrob. Agents Chemother. 2001;45:1151–1161

☆ Address of institution at which the work was performed: NewYork-Presbyterian Hospital, Columbia University Medical Center, 177 Fort Washington Avenue, New York, NY 10032.

PII: S0732-8893(10)00037-4

doi: 10.1016/j.diagmicrobio.2010.02.001

Diagnostic Microbiology & Infectious Disease
Volume 67, Issue 2 , Pages 180-184 , June 2010

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