Diagnostic Microbiology & Infectious Disease
Volume 67, Issue 3 , Pages 277-281, July 2010

Epidemiology of Escherichia coli clinical isolates producing AmpC plasmidic β-lactamase during a 5-year period in a French teaching Hospital☆

  • Stéphane Corvec

      Affiliations

    • CHU de Nantes, Service de Bactériologie-Hygiène, 44093 Nantes, France
    • Université de Nantes, EA3826 Thérapeutiques cliniques et expérimentales des infections, UFR de Médecine, 44000 Nantes, France
    • Corresponding Author InformationCorresponding author. CHU de Nantes, Service de Bactériologie-Hygiène, Nantes, France. Tel.: +33-2-40-08-39-55; fax: +33-2-40-08-39-28.
    • ,
  • Lise Crémet

      Affiliations

    • CHU de Nantes, Service de Bactériologie-Hygiène, 44093 Nantes, France
    • ,
  • Céline Leprince

      Affiliations

    • CHU de Nantes, Service de Bactériologie-Hygiène, 44093 Nantes, France
    • ,
  • Sandie Dauvergne

      Affiliations

    • Université de Nantes, EA3826 Thérapeutiques cliniques et expérimentales des infections, UFR de Médecine, 44000 Nantes, France
    • ,
  • Alain Reynaud

      Affiliations

    • CHU de Nantes, Service de Bactériologie-Hygiène, 44093 Nantes, France
    • Université de Nantes, EA3826 Thérapeutiques cliniques et expérimentales des infections, UFR de Médecine, 44000 Nantes, France
    • ,
  • Didier Lepelletier

      Affiliations

    • CHU de Nantes, Service de Bactériologie-Hygiène, 44093 Nantes, France
    • Université de Nantes, EA3826 Thérapeutiques cliniques et expérimentales des infections, UFR de Médecine, 44000 Nantes, France
    • ,
  • Nathalie Caroff

      Affiliations

    • Université de Nantes, EA3826 Thérapeutiques cliniques et expérimentales des infections, UFR de Médecine, 44000 Nantes, France

Received 10 November 2009; accepted 12 February 2010. published online 12 May 2010.

Abstract 

We investigated the prevalence and epidemiology of AmpC plasmidic cephalosporinases in Escherichia coli clinical strains resistant to third-generation cephalosporins during a 5-year period at Nantes University Hospital, France (3100 beds). The prevalence and diversity of plasmidic cephalosporinase did not increase during the study period (0.09% of 25 861 E. coli isolates); only CMY-2 producers were detected (and 1 new variant, with a Y-to-C substitution at position 219). CMY-2–producing strains belonged to the 4 main phylogenetic groups and to 11 different sequence types. Three sequence types included more than 1 isolate (ST156, ST46, and ST354).

Keywords: Escherichia coli, Cephalosporinase AmpC, CMY-2, MLST

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☆ This work was partially funded by grants from the Ministère de l’Education Nationale et de la Recherche (EA3826), Universités de Nantes, France.

PII: S0732-8893(10)00043-X

doi:10.1016/j.diagmicrobio.2010.02.007

Diagnostic Microbiology & Infectious Disease
Volume 67, Issue 3 , Pages 277-281, July 2010

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