Diagnostic Microbiology & Infectious Disease
Volume 67, Issue 3 , Pages 220-227, July 2010

Campylobacter jejuni and Campylobacter coli in children from communities in Northeastern Brazil: molecular detection and relation to nutritional status☆

  • Josiane da Silva Quetz

      Affiliations

    • Institute of Biomedicine for Brazilian Semi-Arid and Clinical Research Unit/Center for Global Health, Federal University of Ceara, Fortaleza, CE 60430-270, Brazil
    • Corresponding Author InformationCorresponding author. Rua Coronel Nunes de Melo, 1315, Rodolfo Teófilo—Fortaleza, Ceará CEP: 60.430-270, Brazil. Tel.: +55-85-3366-8437; fax: +55-85-3366-8445.
    • ,
  • Ila Fernanda Nunes Lima

      Affiliations

    • Institute of Biomedicine for Brazilian Semi-Arid and Clinical Research Unit/Center for Global Health, Federal University of Ceara, Fortaleza, CE 60430-270, Brazil
    • ,
  • Alexandre Havt

      Affiliations

    • Institute of Biomedicine for Brazilian Semi-Arid and Clinical Research Unit/Center for Global Health, Federal University of Ceara, Fortaleza, CE 60430-270, Brazil
    • ,
  • Eunice Bobo de Carvalho

      Affiliations

    • Institute of Biomedicine for Brazilian Semi-Arid and Clinical Research Unit/Center for Global Health, Federal University of Ceara, Fortaleza, CE 60430-270, Brazil
    • ,
  • Noélia Leal Lima

      Affiliations

    • Institute of Biomedicine for Brazilian Semi-Arid and Clinical Research Unit/Center for Global Health, Federal University of Ceara, Fortaleza, CE 60430-270, Brazil
    • ,
  • Alberto Melo Soares

      Affiliations

    • Institute of Biomedicine for Brazilian Semi-Arid and Clinical Research Unit/Center for Global Health, Federal University of Ceara, Fortaleza, CE 60430-270, Brazil
    • ,
  • Rosa Maria Salani Mota

      Affiliations

    • Science Center/Unit of Statistics, Federal University of Ceara, Fortaleza, CE 60455-760, Brazil
    • ,
  • Richard Littleton Guerrant

      Affiliations

    • Institute of Biomedicine for Brazilian Semi-Arid and Clinical Research Unit/Center for Global Health, Federal University of Ceara, Fortaleza, CE 60430-270, Brazil
    • Center for Global Health, University of Virginia, Charlottesville, VA 22908, USA
    • ,
  • Aldo Angelo Moreira Lima

      Affiliations

    • Institute of Biomedicine for Brazilian Semi-Arid and Clinical Research Unit/Center for Global Health, Federal University of Ceara, Fortaleza, CE 60430-270, Brazil
    • Center for Global Health, University of Virginia, Charlottesville, VA 22908, USA

Received 6 November 2009; accepted 28 February 2010.

Abstract 

This study determined the prevalence of Campylobacter jejuni/coli and its relation with nutritional status in children from Northeastern Brazil. This was a case-control study design. Stool samples were evaluated for hipO (C. jejuni), ask (C. coli), and cdtABC (C. jejuni's cytolethal distending toxin) genes. The nutritional status from these children was assessed by anthropometric measures and z-scores. C. jejuni and C. coli were detected in 9.6% (8/83) and 6.0% (5/83) in the diarrhea group and in 7.2% (6/83) and 1.2% (1/83) of the nondiarrhea group, respectively. Children with positive molecular detection of C. jejuni showed significantly lower z-scores than children without C. jejuni. The cdtABC operon was found in 57% of hipO+ samples. C. jejuni/coli prevalence was similar in diarrhea and nondiarrhea groups. There was a significant association of C. jejuni infection with lower nutritional status.

Keywords: Campylobacteriosis, Campylobacter jejuni, Campylobacter coli, Malnutrition, Diarrheal diseases

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☆ This study was financially supported by Fogarty Clinical Research Training Scholars and Fellows Program (grants 3D43TW006578-04S1, 3D43TW006578-05S1, and 5R24TW007988) and National Institute of Allergy and Infectious Diseases—NIAID (grant 2U01AI026512-17) from US National Institutes of Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq (grants 141663/2005-7, 484747/2007-0 and 140242/2009-0) and Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico—FUNCAP (grant 2911/06) from Brazil.

PII: S0732-8893(10)00081-7

doi:10.1016/j.diagmicrobio.2010.02.025

Diagnostic Microbiology & Infectious Disease
Volume 67, Issue 3 , Pages 220-227, July 2010

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