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The role of newer orally administered cephalosporins in contemporary outpatient practice
Oral β-lactams are among the most widely used antimicrobial agents in the outpatient care environment, and derivatives have evolved considerably since the introduction of penicillin. The discovery of ...
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James A. Hadley,
Thomas R. Fritsche
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S1-S3
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Review of the spectrum and potency of orally administered cephalosporins and amoxicillin/clavulanate
Abstract: The antimicrobial spectrum and in vitro potency of the most frequently prescribed orally administered cephalosporins (cefaclor, cefdinir, cefpodoxime, cefprozil, cefuroxime axetil, cephalexi...
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Helio S. Sader,
Michael R. Jacobs,
Thomas R. Fritsche
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S5-S12
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Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift
Abstract: Recent analysis of clinical data and a clearer understanding of the role of chemical structure in the development of cross-reactivity indicate that the increased risk of an allergic reaction...
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Michael E. Pichichero
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S13-S18
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Oral β-lactams in the treatment of acute otitis media
Abstract: Acute otitis media (AOM) is an important infectious disease among children throughout the world. The management of AOM is complicated by difficulties in diagnosis, spontaneous resolution, al...
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Stan L. Block,
Gary V. Doern,
Michael A. Pfaller
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S19-S30
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Role of oral extended-spectrum cephems in the treatment of acute exacerbation of chronic bronchitis
Abstract: Risk stratification is the recommended approach for treatment of acute exacerbation of chronic bronchitis (AECB) to optimize the chances of clinical success. The suggested oral therapy for “...
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Antonio Anzueto,
William R. Bishai,
Sudha Pottumarthy
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S31-S38
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The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis
Abstract: Current treatment guidelines from the Infectious Diseases Society of America, the American Heart Association, and the American Academy of Pediatrics recommend only oral penicillin V or intra...
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Janet R. Casey,
Michael E. Pichichero
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S39-S45
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Oral β-lactams in the treatment of acute bacterial rhinosinusitis
Abstract: Acute bacterial rhinosinusitis (ABRS) is a well-known complication of viral upper respiratory tract infection and is associated with a significant socioeconomic burden. Difficulties in diagn...
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James A. Hadley,
Michael A. Pfaller
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S47-S54
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Oral β-lactams applied to uncomplicated infections of skin and skin structures
Abstract: Uncomplicated skin and skin structure infections (uSSSIs) include impetigo, erysipelas, folliculitis, simple abscesses, and cellulitis. Their common bacterial causative agents include Staphy...
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Michael R. Jacobs,
Ronald N. Jones,
Philip A. Giordano
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S55-S65
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Adverse events associated with the use of oral cephalosporins/cephems
Abstract: Historically, oral cephalosporins represent one of the most widely used and safest classes of antimicrobials available. Typical adverse events have included nausea, vomiting, diarrhea, and h...
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Isaac F. Mitropoulos,
John C. Rotschafer,
Keith A. Rodvold
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S67-S76
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Antimicrobial stewardship and the role of pharmacokinetics–pharmacodynamics in the modern antibiotic era
Abstract: Antimicrobial stewardship, a term coined by Dale Gerding, is defined as the optimal selection, dose, and duration of an antimicrobial that results in the best clinical outcome for the treatm...
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Robert C. Owens,
Paul G. Ambrose
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S77-S83
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